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Ativan (Lorazepam) is intended for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms. Tension or anxiety associated with the stress of everyday life usually does not require treatment with an anxiolytic.
The effectivity of Ativan in long-term use (more than 4 months) has not been assessed by systematic clinical studies. The physician should reassess the usefulness of the drug for the individual patient periodically.
Ativan is orally administered. To get optimal results, dose, frequency of administration, and duration of therapy should be individualized according to patient response. To obtain this, Ativan is available in 0.5 mg, 1 mg, and 2 mg tablets. The usual dose is 2 to 6 mg/day to be given in divided doses, with the highest dose taken before bedtime, but the daily dosage may vary from 1 to 10 mg per day.
Most patients with anxiety require an initial dose of 2 to 3 mg per day given twice a day or thrice a day. For insomnia due to anxiety or transient situational stress, a single daily dose of 2 to 4 mg may be given at bedtime. An initial dosage of 1 to 2 mg/day in divided doses is recommended for elderly and debilitated patients to be adjusted as needed and tolerated. Incidence of sedation and unsteadiness was observed to have increased with age.
The dosage of Ativan (Lorazepam) should be gradually increased when needed to help avoid adverse effects. If a higher dosage is indicated, the evening dose should be increased before the daytime doses.
Patients should be told that, since benzodiazepines may produce psychological and physical dependence, it is advisable that they consult with their physician before either increasing the dose or abruptly discontinuing this drug.